InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hbb-b1

Summary

InnateDB Gene

IDBG-203683.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hbb-b1

Gene Name

hemoglobin, beta adult major chain

Synonyms

AA409645; AI036344; beta1; beta2; Hbb1; Hbb2; Hbbt1; Hbbt2; MommeD7

Species

Mus musculus

Ensembl Gene

ENSMUSG00000052305

Encoded Proteins

IDBP-203685

hemoglobin, beta adult major chain

IDBP-534695

hemoglobin, beta adult major chain

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a beta polypeptide chain found in adult hemoglobin, which consists of a tetramer of two alpha chains and two beta chains, and which functions in the transport of oxygen to various peripheral tissues. This gene is one of a cluster of beta-hemoglobin genes that are distally regulated by a locus control region, and which are organized along the chromosome in the order of their developmental expression. In mouse, two major strain-specific haplotypes of the beta-globin gene cluster are found - a "single" haplotype found in C57BL/-type strains, which includes two highly similar adult beta-globin genes, beta s and beta t, and a "diffuse" haplotype found in strains such as BALB/c and 129Sv, which includes two somewhat diverse adult beta-globin genes, beta-major and beta-minor. This gene represents the beta-major adult gene found in the "diffuse" haplotype. Primary chromosome 7 of the mouse reference genome assembly, which is derived from C57BL/6 strain mice, represents the "single" haplotype, while the "diffuse" haplotype is represented in the reference genome collection by the BALB/c strain alternate contig, NT_095534.1. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:103826534-103828096

Strand

Reverse strand

Band

Transcripts

ENSMUST00000023934	ENSMUSP00000023934
ENSMUST00000131960
ENSMUST00000153218	ENSMUSP00000115607

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005344	oxygen transporter activity
GO:0005506	iron ion binding
GO:0019825	oxygen binding
GO:0020037	heme binding

Biological Process

GO:0015671

oxygen transport

Cellular Component

GO:0005833

hemoglobin complex

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

KEGG

mmu05144

Malaria pathway

mmu05143

African trypanosomiasis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

A8DUK4 E9Q223

UniProt Splice Variant

Entrez Gene

15130

UniGene

RefSeq

NM_001201391 NM_001278161

OMIM

CCDS

CCDS52339

HPRD

IMGT

MGI ID

MGI:5474852

MGI Symbol

Hbb-bs

EMBL

AC131116 EF605350 EF605351 EF605353 EF605360 EF605362 EF605363 EF605364 EF605370 EF605373 EF605379 EF605381 EF605382 EF605383 EF605475 EF605476 EF605477 EF605478 EF605479 EF605480 EF605481 EF605482 EF605488 EF605499 EF605500 EF605501 EF605502 EF605503 EF605504 EF605508 GQ250376 GQ250391

GenPept

ABU63178 ABU63179 ABU63181 ABU63188 ABU63190 ABU63191 ABU63192 ABU63198 ABU63201 ABU63207 ABU63209 ABU63210 ABU63211 ABU63254 ABU63255 ABU63256 ABU63257 ABU63258 ABU63259 ABU63260 ABU63261 ABU63267 ABU63278 ABU63279 ABU63280 ABU63281 ABU63282 ABU63283 ABU63287 ACY03375 ACY03390

RNA Seq Atlas

100503605 101488143 15129 15130