Version 5.4
Mus musculus Gene: Azi2
Summary
InnateDB Gene IDBG-204092.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Azi2
Gene Name 5-azacytidine induced gene 2
Synonyms AA410145; AZ2
Species Mus musculus
Ensembl Gene ENSMUSG00000039285
Encoded Proteins
IDBP-204096
5-azacytidine induced gene 2
IDBP-535306
5-azacytidine induced gene 2
IDBP-537912
5-azacytidine induced gene 2
IDBP-539629
5-azacytidine induced gene 2
IDBP-542633
5-azacytidine induced gene 2
IDBP-534937
5-azacytidine induced gene 2
IDBP-540081
5-azacytidine induced gene 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 17142768
[Homo sapiens] AZI2 participates in both the TLR3-mediated and the cytoplasmic DDX58 (RIG-I) dsRNA recognition pathways in type-1 interferon (IFN) induction by binding to MAVS, DDX58 and IFIH1 (MDA5).
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163512:
AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003 [PubMed 14560022]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:118040499-118069794
Strand Forward strand
Band F3
Transcripts
ENSMUST00000044454 ENSMUSP00000044350
ENSMUST00000133580 ENSMUSP00000118765
ENSMUST00000134433 ENSMUSP00000114980
ENSMUST00000154583 ENSMUSP00000122063
ENSMUST00000143024
ENSMUST00000130735 ENSMUSP00000114634
ENSMUST00000127189
ENSMUST00000135251 ENSMUSP00000116971
ENSMUST00000133814
ENSMUST00000123690 ENSMUSP00000121245
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0001816 cytokine production
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0032607 interferon-alpha production
GO:0032609 interferon-gamma production
GO:0032635 interleukin-6 production
GO:0032640 tumor necrosis factor production
GO:0042110 T cell activation
GO:0044565 dendritic cell proliferation
GO:0097028 dendritic cell differentiation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000163512
View Gene Order
ENSBTAG00000004117
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04622
RIG-I-like receptor signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04622
RIG-I-like receptor signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.387529 Mm.474919 Mm.92705
RefSeq NM_001048146 NM_001286507 NM_013727
OMIM
CCDS CCDS40799 CCDS52959
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca