InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Vangl2

Summary

InnateDB Gene

IDBG-204899.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vangl2

Gene Name

vang-like 2 (van gogh, Drosophila)

Synonyms

C530001F03Rik; loop-tail; Lp; Lpp1; Ltap; ska; ska17; stbm; strabismus; Vang1l2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026556

Encoded Proteins

IDBP-204901

vang-like 2 (van gogh, Drosophila)

IDBP-258506

vang-like 2 (van gogh, Drosophila)

IDBP-258508

vang-like 2 (van gogh, Drosophila)

IDBP-532504

vang-like 2 (van gogh, Drosophila)

IDBP-534878

vang-like 2 (van gogh, Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162738:
The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:172000960-172028444

Strand

Reverse strand

Band

Transcripts

ENSMUST00000027837	ENSMUSP00000027837
ENSMUST00000111264	ENSMUSP00000106895
ENSMUST00000111263	ENSMUSP00000106894
ENSMUST00000148363
ENSMUST00000153662	ENSMUSP00000116522
ENSMUST00000138714	ENSMUSP00000117736

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	4 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001569	patterning of blood vessels
GO:0001736	establishment of planar polarity
GO:0001843	neural tube closure
GO:0001942	hair follicle development
GO:0001947	heart looping
GO:0003148	outflow tract septum morphogenesis
GO:0003149	membranous septum morphogenesis
GO:0003150	muscular septum morphogenesis
GO:0003347	epicardial cell to mesenchymal cell transition
GO:0003402	planar cell polarity pathway involved in axis elongation
GO:0007266	Rho protein signal transduction
GO:0007275	multicellular organismal development
GO:0009952	anterior/posterior pattern specification
GO:0022007	convergent extension involved in neural plate elongation
GO:0030111	regulation of Wnt signaling pathway
GO:0032835	glomerulus development
GO:0032956	regulation of actin cytoskeleton organization
GO:0035019	somatic stem cell maintenance
GO:0035058	nonmotile primary cilium assembly
GO:0035567	non-canonical Wnt signaling pathway
GO:0035787	cell migration involved in kidney development
GO:0036342	post-anal tail morphogenesis
GO:0042060	wound healing
GO:0043507	positive regulation of JUN kinase activity
GO:0045176	apical protein localization
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity
GO:0048103	somatic stem cell division
GO:0048105	establishment of body hair planar orientation
GO:0048546	digestive tract morphogenesis
GO:0060028	convergent extension involved in axis elongation
GO:0060029	convergent extension involved in organogenesis
GO:0060071	Wnt signaling pathway, planar cell polarity pathway
GO:0060119	inner ear receptor cell development
GO:0060122	inner ear receptor stereocilium organization
GO:0060488	orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis
GO:0060489	planar dichotomous subdivision of terminal units involved in lung branching morphogenesis
GO:0060490	lateral sprouting involved in lung morphogenesis
GO:0060947	cardiac vascular smooth muscle cell differentiation
GO:0060993	kidney morphogenesis
GO:0061346	planar cell polarity pathway involved in heart morphogenesis
GO:0090102	cochlea development
GO:0090103	cochlea morphogenesis
GO:0090162	establishment of epithelial cell polarity
GO:0090175	regulation of establishment of planar polarity
GO:0090177	establishment of planar polarity involved in neural tube closure
GO:0090179	planar cell polarity pathway involved in neural tube closure

Cellular Component

GO:0001725	stress fiber
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0016328	lateral plasma membrane
GO:0030134	ER to Golgi transport vesicle
GO:0060187	cell pole
GO:0071944	cell periphery