Version 5.4
Homo sapiens Gene: NPTN
Summary
InnateDB Gene IDBG-21125.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NPTN
Gene Name neuroplastin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000156642
Encoded Proteins
IDBP-21127
neuroplastin
IDBP-21129
neuroplastin
IDBP-745366
IDBP-746184
IDBP-746556
IDBP-744718
IDBP-747074
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:73560014-73634134
Strand Reverse strand
Band q24.1
Transcripts
ENST00000345330 ENSP00000290401
ENST00000351217 ENSP00000342958
ENST00000562924 ENSP00000456349
ENST00000563753
ENST00000564551
ENST00000563691 ENSP00000457028
ENST00000567198 ENSP00000455671
ENST00000565282 ENSP00000456033
ENST00000565325 ENSP00000457470
ENST00000561898
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005105 type 1 fibroblast growth factor receptor binding
GO:0005515 protein binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0007156 homophilic cell adhesion
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0010976 positive regulation of neuron projection development
GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway
GO:0048170 positive regulation of long-term neuronal synaptic plasticity
GO:0060291 long-term synaptic potentiation
Cellular Component
GO:0016021 integral component of membrane
GO:0042734 presynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032336
View Gene Order
ENSBTAG00000008218
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.704983
RefSeq NM_001161363 NM_001161364 NM_012428 NM_017455
HUGO
OMIM
CCDS CCDS10249 CCDS10250 CCDS58379 CCDS58380
HPRD 18033
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca