Version 5.4
Homo sapiens Gene: RFTN1
Summary
InnateDB Gene IDBG-21351.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RFTN1
Gene Name raftlin, lipid raft linker 1
Synonyms PIB10; PIG9; RAFTLIN
Species Homo sapiens
Ensembl Gene ENSG00000131378
Encoded Proteins
IDBP-21353
raftlin, lipid raft linker 1
IDBP-366738
raftlin, lipid raft linker 1
IDBP-366755
raftlin, lipid raft linker 1
IDBP-366759
raftlin, lipid raft linker 1
IDBP-366765
raftlin, lipid raft linker 1
IDBP-366768
raftlin, lipid raft linker 1
IDBP-366769
raftlin, lipid raft linker 1
IDBP-812736
raftlin, lipid raft linker 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21266579
RFTN1 cooperates with the uptake receptor to mediate cell entry of poly(I:C), which is critical for activation of TLR3 and the subsequent production of IFN and inflammatory cytokines.
InnateDB Annotation from Orthologs
Summary
PMID 21266579
[Mus musculus] Rftn1 cooperates with the uptake receptor to mediate cell entry of poly(I:C), which is critical for activation of Tlr3 and the subsequent production of IFN and inflammatory cytokines.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 3:16313574-16514026
Strand Reverse strand
Band p24.3
Transcripts
ENST00000334133 ENSP00000334153
ENST00000432519 ENSP00000403926
ENST00000451036 ENSP00000403997
ENST00000441460 ENSP00000388718
ENST00000449415 ENSP00000409427
ENST00000453536 ENSP00000410493
ENST00000431547 ENSP00000393216
ENST00000483671
ENST00000495666
ENST00000484752
ENST00000470458
ENST00000607320 ENSP00000475367
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003725 double-stranded RNA binding
Biological Process
GO:0001765 membrane raft assembly
GO:0002457 T cell antigen processing and presentation
GO:0032596 protein transport into membrane raft
GO:0032620 interleukin-17 production
GO:0033227 dsRNA transport
GO:0034138 toll-like receptor 3 signaling pathway
GO:0040007 growth
GO:0043330 response to exogenous dsRNA
GO:0045087 innate immune response (InnateDB)
GO:0050852 T cell receptor signaling pathway
GO:0050853 B cell receptor signaling pathway
GO:1903044 protein localization to membrane raft
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0043234 protein complex
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000039316
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.665363 Hs.98910
RefSeq NM_015150 XM_005264985 XM_005264986 XM_005264987 XM_006713069
HUGO
OMIM
CCDS CCDS33712
HPRD 17950
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca