Version 5.4
Homo sapiens Gene: FAM59A
Summary
InnateDB Gene IDBG-2231.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAM59A
Gene Name family with sequence similarity 59, member A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000141441
Encoded Proteins
IDBP-2233
family with sequence similarity 59, member A
IDBP-231170
family with sequence similarity 59, member A
IDBP-726567
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an adaptor protein which functions in the epidermal growth factor (EGF) receptor-mediated signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:32124877-32470484
Strand Reverse strand
Band q12.1
Transcripts
ENST00000269209 ENSP00000269209
ENST00000399218 ENSP00000382165
ENST00000578619
ENST00000583696 ENSP00000464185
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0070064 proline-rich region binding
Biological Process
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0051781 positive regulation of cell division
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071364 cellular response to epidermal growth factor stimulus
Cellular Component
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042680
View Gene Order
ENSBTAG00000020286
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9H706
TrEMBL B4DME6
UniProt Splice Variant
Entrez Gene 64762
UniGene Hs.444314 Hs.603239 Hs.609583
RefSeq NM_022751 NM_001242409
HUGO HGNC:26136
OMIM
CCDS CCDS11905 CCDS56057
HPRD 12685
IMGT
EMBL AK025263 AK297430 AL834491 BC005074 BC121067 BC121068
GenPept AAH05074 AAI21068 AAI21069 BAB15094 BAG59858 CAD39149
RNA Seq Atlas 64762

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca