InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ACAA1

Summary

InnateDB Gene

IDBG-25581.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACAA1

Gene Name

acetyl-CoA acyltransferase 1

Synonyms

ACAA; PTHIO; THIO

Species

Homo sapiens

Ensembl Gene

ENSG00000060971

Encoded Proteins

IDBP-25583

acetyl-CoA acyltransferase 1

IDBP-25585

acetyl-CoA acyltransferase 1

IDBP-371875

acetyl-CoA acyltransferase 1

IDBP-371900

acetyl-CoA acyltransferase 1

IDBP-371903

acetyl-CoA acyltransferase 1

IDBP-371904

acetyl-CoA acyltransferase 1

IDBP-371905

acetyl-CoA acyltransferase 1

IDBP-371906

acetyl-CoA acyltransferase 1

IDBP-371907

acetyl-CoA acyltransferase 1

IDBP-371909

acetyl-CoA acyltransferase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an enzyme operative in the beta-oxidation system of the peroxisomes. Deficiency of this enzyme leads to pseudo-Zellweger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:38103129-38137242

Strand

Reverse strand

Band

p22.2

Transcripts

ENST00000333167	ENSP00000333664
ENST00000301810	ENSP00000301810
ENST00000411549	ENSP00000414021
ENST00000450296	ENSP00000395183
ENST00000452171	ENSP00000391078
ENST00000421218	ENSP00000398172
ENST00000440176	ENSP00000389226
ENST00000423611	ENSP00000396485
ENST00000447223	ENSP00000405785
ENST00000418880	ENSP00000403124
ENST00000469559
ENST00000480865
ENST00000469600
ENST00000465181
ENST00000484284
ENST00000460424
ENST00000489559

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003988	acetyl-CoA C-acyltransferase activity
GO:0005515	protein binding
GO:0016401	palmitoyl-CoA oxidase activity
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups

Biological Process

GO:0000038	very long-chain fatty acid metabolic process
GO:0006635	fatty acid beta-oxidation
GO:0008152	metabolic process
GO:0008206	bile acid metabolic process
GO:0008610	lipid biosynthetic process
GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase
GO:0033559	unsaturated fatty acid metabolic process
GO:0036109	alpha-linolenic acid metabolic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response

Cellular Component

GO:0005777	peroxisome
GO:0005782	peroxisomal matrix
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

REACT_17062

Beta-oxidation of very long chain fatty acids pathway

REACT_121147

alpha-linolenic acid (ALA) metabolism pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_16957

Peroxisomal lipid metabolism pathway

REACT_121284

alpha-linolenic (omega3) and linoleic (omega6) acid metabolism pathway

REACT_111217

Metabolism pathway

KEGG

hsa00592

alpha-Linolenic acid metabolism pathway

hsa00280

Valine, leucine and isoleucine degradation pathway

hsa01040

Biosynthesis of unsaturated fatty acids pathway

hsa00071

Fatty acid degradation pathway

hsa03320

PPAR signaling pathway pathway

hsa04146

Peroxisome pathway

INOH

INOH website

Valine Leucine Isoleucine degradation pathway

PID NCI

Cross-References

SwissProt

TrEMBL

F2Z2Q6

UniProt Splice Variant

Entrez Gene

UniGene

Hs.643487

RefSeq

NM_001130410 NM_001607 XM_006713122

HUGO

HGNC:82

OMIM

604054

CCDS

CCDS2673 CCDS46794

HPRD

06815

IMGT

EMBL

AP006309

GenPept

RNA Seq Atlas