Version 5.4
Homo sapiens Gene: FREM2
Summary
InnateDB Gene IDBG-25954.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FREM2
Gene Name FRAS1 related extracellular matrix protein 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000150893
Encoded Proteins
IDBP-25956
FRAS1 related extracellular matrix protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a membrane protein that belongs to the FRAS1 family. This extracellular matrix protein is thought to be required for maintaining the integrity of the skin epithelium and the differentiated state of renal epithelia. The protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions during morphogenetic processes. Mutations in this gene are associated with Fraser syndrome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:38687129-38887131
Strand Forward strand
Band q13.3
Transcripts
ENST00000280481 ENSP00000280481
ENST00000482551
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 2 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0002009 morphogenesis of an epithelium
GO:0007154 cell communication
GO:0007156 homophilic cell adhesion
GO:0048839 inner ear development
Cellular Component
GO:0005604 basement membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037016
View Gene Order
ENSBTAG00000017032
Not yet available
Cross-References
SwissProt Q5SZK8
TrEMBL
UniProt Splice Variant
Entrez Gene 341640
UniGene Hs.253994 Hs.613456
RefSeq NM_207361
HUGO HGNC:25396
OMIM 608945
CCDS CCDS31960
HPRD
IMGT
EMBL AC017111 AK127571 AL354819 AL590007 BN000687 BX538150 BX538304 BX640686 CR933724
GenPept BAC87040 CAD98036 CAD98088 CAE45813 CAH56764 CAI12790 CAI16761 CAI46253
RNA Seq Atlas 341640

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca