Version 5.4
Homo sapiens Gene: DCSTAMP
Summary
InnateDB Gene IDBG-32021.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCSTAMP
Gene Name dendrocyte expressed seven transmembrane protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000164935
Encoded Proteins
IDBP-32023
transmembrane 7 superfamily member 4
IDBP-480696
transmembrane 7 superfamily member 4
IDBP-810697
dendrocyte expressed seven transmembrane protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a seven-pass transmembrane protein that is primarily expressed in dendritic cells. The encoded protein is involved in a range of immunological functions carried out by dendritic cells. This protein plays a role in osteoclastogenesis and myeloid differentiation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:104339087-104356689
Strand Forward strand
Band q22.3
Transcripts
ENST00000297581 ENSP00000297581
ENST00000519562
ENST00000517364
ENST00000518023
ENST00000517991 ENSP00000428869
ENST00000518051
ENST00000520080
ENST00000622554 ENSP00000480546
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
Biological Process
GO:0006810 transport
GO:0030308 negative regulation of cell growth
GO:0030316 osteoclast differentiation
GO:0034241 positive regulation of macrophage fusion
GO:0036006 cellular response to macrophage colony-stimulating factor stimulus
GO:0043011 myeloid dendritic cell differentiation
GO:0045657 positive regulation of monocyte differentiation
GO:0045780 positive regulation of bone resorption
GO:0055085 transmembrane transport
GO:0061025 membrane fusion
GO:0071353 cellular response to interleukin-4
GO:0071356 cellular response to tumor necrosis factor
GO:0072675 osteoclast fusion
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0016021 integral component of membrane
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022303
View Gene Order
ENSBTAG00000021240
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.652230 Hs.741954
RefSeq NM_001257317 NM_030788 XM_005251075
HUGO
OMIM
CCDS CCDS59111 CCDS6301
HPRD 07295
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca