Version 5.4
Homo sapiens Gene: CCL17
Summary
InnateDB Gene IDBG-33236.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCL17
Gene Name chemokine (C-C motif) ligand 17
Synonyms A-152E5.3; ABCD-2; SCYA17; TARC
Species Homo sapiens
Ensembl Gene ENSG00000102970
Encoded Proteins
IDBP-33238
chemokine (C-C motif) ligand 17
IDBP-807827
chemokine (C-C motif) ligand 17
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18191727
IL4 (Interleukin-4) induces CCL17 expression via two STAT6 motifs in the proximal promoter and a distal tandem STAT6 element
PMID 22057112
CCL17 is required for the induction of intestinal inflammation in mice. CCL17 has an autocrine effect on dendritic cells that promotes production of inflammatory cytokines and activation of Th1 and Th17 cells and reduces expansion of Treg cells. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
PMID 22057112
[Mus musculus] Ccl17 is required for the induction of intestinal inflammation in mice. Ccl17 has an autocrine effect on dendritic cells that promotes production of inflammatory cytokines and activation of Th1 and Th17 cells and reduces expansion of Treg cells.
Entrez Gene
Summary This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. [provided by RefSeq, Jul 2008]
This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:57404767-57416062
Strand Forward strand
Band q21
Transcripts
ENST00000219244 ENSP00000219244
ENST00000616880 ENSP00000480147
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 6 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0008009 chemokine activity
GO:0031729 CCR4 chemokine receptor binding
Biological Process
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0007275 multicellular organismal development
GO:0045087 innate immune response (InnateDB)
GO:0060326 cell chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000031780
View Gene Order
Pathways
NETPATH
REACTOME
REACT_15344
Chemokine receptors bind chemokines pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04062
Chemokine signaling pathway pathway
INOH
PID NCI
il4_2pathway
IL4-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_002987
HUGO
OMIM
CCDS CCDS10780
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca