Version 5.4
Homo sapiens Gene: LLGL1
Summary
InnateDB Gene IDBG-33645.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LLGL1
Gene Name lethal giant larvae homolog 1 (Drosophila)
Synonyms DLG4; HUGL; HUGL-1; HUGL1; LLGL
Species Homo sapiens
Ensembl Gene ENSG00000131899
Encoded Proteins
IDBP-33647
lethal giant larvae homolog 1 (Drosophila)
IDBP-811713
lethal giant larvae homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:18225587-18244875
Strand Forward strand
Band p11.2
Transcripts
ENST00000316843 ENSP00000321537
ENST00000479155
ENST00000621229 ENSP00000480006
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005097 Rab GTPase activator activity
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0006461 protein complex assembly
GO:0006887 exocytosis
GO:0006893 Golgi to plasma membrane transport
GO:0007409 axonogenesis
GO:0030866 cortical actin cytoskeleton organization
GO:0032851 positive regulation of Rab GTPase activity
GO:0035090 maintenance of apical/basal cell polarity
Cellular Component
GO:0000137 Golgi cis cisterna
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0030424 axon
GO:0030864 cortical actin cytoskeleton
GO:0031901 early endosome membrane
GO:0032588 trans-Golgi network membrane
GO:0035748 myelin sheath abaxonal region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020536
View Gene Order
ENSBTAG00000004635
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04530
Tight junction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_004140 XM_005256643 XM_005256644
HUGO
OMIM
CCDS CCDS32586
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca