Version 5.4
Homo sapiens Gene: KRT74
Summary
InnateDB Gene IDBG-34765.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRT74
Gene Name keratin 74
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000170484
Encoded Proteins
IDBP-34769
keratin 74
IDBP-597334
keratin 74
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This protein belongs to a family of keratins that are specifically expressed in the inner root sheath of hair follicles.[provided by RefSeq, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:52565782-52573825
Strand Reverse strand
Band q13.13
Transcripts
ENST00000305620 ENSP00000307240
ENST00000549343 ENSP00000447447
ENST00000546384
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:1990254 keratin filament binding
Biological Process
GO:0045104 intermediate filament cytoskeleton organization
Cellular Component
GO:0005737 cytoplasm
GO:0005882 intermediate filament
GO:0045095 keratin filament
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.660125
RefSeq NM_175053
HUGO
OMIM
CCDS CCDS8832
HPRD 10504
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca