Version 5.4
Homo sapiens Gene: GYPB
Summary
InnateDB Gene IDBG-408950.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GYPB
Gene Name glycophorin B (MNS blood group)
Synonyms CD235b; GPB; GPB.NY; GpMiIII; GYPHe.NY; HGpMiIII; HGpMiVI; HGpMiX; MNS; PAS-3; SS
Species Homo sapiens
Ensembl Gene ENSG00000250361
Encoded Proteins
IDBP-378102
glycophorin B (MNS blood group)
IDBP-479762
glycophorin B (MNS blood group)
IDBP-483006
glycophorin B (MNS blood group)
IDBP-484767
glycophorin B (MNS blood group)
IDBP-474891
glycophorin B (MNS blood group)
IDBP-484414
glycophorin B (MNS blood group)
IDBP-484633
glycophorin B (MNS blood group)
IDBP-478190
glycophorin B (MNS blood group)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. [provided by RefSeq, Jul 2008]
Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97%% sequence homology with GYPA from the 5\' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:143996104-144019345
Strand Reverse strand
Band q31.21
Transcripts
ENST00000429670 ENSP00000394200
ENST00000506679 ENSP00000422726
ENST00000502664 ENSP00000427690
ENST00000507009
ENST00000513128 ENSP00000425244
ENST00000505583 ENSP00000423055
ENST00000506516 ENSP00000424025
ENST00000513557
ENST00000513677
ENST00000511198 ENSP00000423025
ENST00000504951 ENSP00000421974
ENST00000510196
ENST00000503255
ENST00000508618
ENST00000508841
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa05144
Malaria pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_002100 XM_005262969
HUGO
OMIM
CCDS CCDS54809
HPRD 00201
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca