Version 5.4
Homo sapiens Gene: UBASH3A
Summary
InnateDB Gene IDBG-4392.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBASH3A
Gene Name ubiquitin associated and SH3 domain containing A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000160185
Encoded Proteins
IDBP-4394
ubiquitin associated and SH3 domain containing A
IDBP-4396
ubiquitin associated and SH3 domain containing A
IDBP-233182
ubiquitin associated and SH3 domain containing A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:42403899-42447681
Strand Forward strand
Band q22.3
Transcripts
ENST00000319294 ENSP00000317327
ENST00000291535 ENSP00000291535
ENST00000398367 ENSP00000381408
ENST00000473381
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005515 protein binding
Biological Process
GO:0001817 regulation of cytokine production
GO:0008152 metabolic process
GO:0050860 negative regulation of T cell receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042345
View Gene Order
ENSBTAG00000023398
Not yet available
Cross-References
SwissProt P57075
TrEMBL
UniProt Splice Variant
Entrez Gene 53347
UniGene Hs.473912
RefSeq NM_001001895 NM_001243467 NM_018961 XM_006724013
HUGO HGNC:12462
OMIM 605736
CCDS CCDS13687 CCDS33566 CCDS58791
HPRD
IMGT
EMBL AF520809 AF521702 AJ277750 AP001746 BC069357 BC069483 BC069511 BC069577 CH471079
GenPept AAH69357 AAH69483 AAH69511 AAP80731 AAP80738 CAB91543 EAX09560
RNA Seq Atlas 53347

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca