Homo sapiens Gene: IL22
Summary
InnateDB Gene IDBG-46046.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL22
Gene Name interleukin 22
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000127318
Encoded Proteins
interleukin 22
interleukin 22
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
IL22 plays a role in mucosal immunity where it helps constrain inflammation and protect mucosal sites.
IL22 is a member of the IL-10 cytokine family that is produced by special immune cell populations and ts primary effects on target cells include its role in innate immune defence against infections, in tumourigenesis, and in inflammatory diseases.
IL22 increases the TNF-alpha-dependent induction and secretion of several immune-modulatory molecules such as initial complement factors, antimicrobial peptides and chemokines in primary keratinocytes. IL22-mediated induction of innate immunity is crucial for the maintenance of epidermal integrity during infection with Candida albicans.
IL22 is produced by lymphoid tissue-inducer cells where it regulates the maintenance of colonic lymphoid structures during Citrobacter rodentium infection, a mechanism that bridges the lymphotoxin pathway to mucosal epithelial defense mechanisms. (Demonstrated in mice)
IL22 protects intestinal stem cells from inflammatory tissue damage and regulates sensitivity to graft versus host disease.
Stat3 mediates protection against intestinal infection by inducing innate lymphoid cell derived-Il22. (Demonstrated in mice)
IL22 protects against and IL22RA2 aggravates liver fibrosis and cirrhosis in chronic liver infections.
IFNG interferes with the IL-1/NFKBIZ axis in β-glucan-activated dendritic cells and promotes T cell-mediated immune responses with increased release of IFNG and IL22, and diminished production of IL17A.
In alveolar epithelium, IL22 upregulates DEFB4A gene expression via STAT3.
IL22 induced at an early stage of L. monocytogenes infection enhances innate immunity against L. monocytogenes in the liver by stimulating hepatocytes to produce an antimicrobial molecule, PLA2G2A
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Iltifb (Il22b) increases the TNF-alpha-dependent induction and secretion of several immune-modulatory molecules such as initial complement factors, antimicrobial peptides and chemokines in primary keratinocytes. Iltifb-mediated induction of innate immunity is crucial for the maintenance of epidermal integrity during infection with Candida albicans. (Demonstrated in human)
[Mus musculus] Iltifb (Il22) is produced by lymphoid tissue-inducer cells where it regulates the maintenance of colonic lymphoid structures during Citrobacter rodentium infection, a mechanism that bridges the lymphotoxin pathway to mucosal epithelial defense mechanisms.
[Mus musculus] ILTIFB (IL22) protects intestinal stem cells from inflammatory tissue damage and regulates sensitivity to graft versus host disease. (Demonstrated in human)
[Mus musculus] Flagellin induces Tlr5-dependent Il22 production and Nlrc4-dependent Il18 production to promote a protective gene expression program in intestinal epithelial cells and elimination of rotavirus-infected cells.
[Mus musculus] Cxcl16-Cxcr6 crosstalk coordinates the intestinal topography of Il22 secretion required for mucosal defence against Citrobacter rodentium infection.
[Mus musculus] Il22 augments the expression of Il18 mRNA and inactive precursor protein (proIL-18) in intestinal epithelial cells after Toxoplasma gondii or Citrobacter rodentium infection and maintains the homeostatic amount of proIL-18 in the ileum.
[Mus musculus] Innate lymphoid cells, potent producers of Il22 after intestinal injury, increase the growth of mouse small intestine organoids in an Il22-dependent fashion.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 12:68248242-68253607
Strand Reverse strand
Band q15
Transcripts
ENST00000328087 ENSP00000329384
ENST00000538666 ENSP00000442424
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0045518 interleukin-22 receptor binding
Biological Process
GO:0006953 acute-phase response
GO:0006954 inflammatory response
GO:0007267 cell-cell signaling
GO:0045087 innate immune response (InnateDB)
GO:0051384 response to glucocorticoid
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
INOH
PID BIOCARTA
Il22 soluble receptor signaling pathway [Biocarta view]
PID NCI
Cross-References
SwissProt Q9GZX6
TrEMBL
UniProt Splice Variant
Entrez Gene 50616
UniGene Hs.287369
RefSeq NM_020525 XM_005268929
HUGO HGNC:14900
OMIM 605330
CCDS CCDS8982
HPRD 05621
IMGT
EMBL AF279437 AF387519 AJ277247 AJ277248 AY358890 BC066263 BC067510 BC069112 BC069308 BC070261
GenPept AAG22064 AAH66263 AAH67510 AAH69112 AAH69308 AAH70261 AAK62468 AAQ89249 CAC06085 CAC19409
RNA Seq Atlas 50616