Version 5.4
Homo sapiens Gene: SENP7
Summary
InnateDB Gene IDBG-47736.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SENP7
Gene Name SUMO1/sentrin specific peptidase 7
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000138468
Encoded Proteins
IDBP-47738
SUMO1/sentrin specific peptidase 7
IDBP-47742
SUMO1/sentrin specific peptidase 7
IDBP-381899
SUMO1/sentrin specific peptidase 7
IDBP-242269
SUMO1/sentrin specific peptidase 7
IDBP-242271
SUMO1/sentrin specific peptidase 7
IDBP-242273
SUMO1/sentrin specific peptidase 7
IDBP-242275
SUMO1/sentrin specific peptidase 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:101324205-101513241
Strand Reverse strand
Band q12.3
Transcripts
ENST00000314261 ENSP00000313624
ENST00000348610 ENSP00000342159
ENST00000366089 ENSP00000402977
ENST00000394095 ENSP00000377655
ENST00000394094 ENSP00000377654
ENST00000394091 ENSP00000377651
ENST00000394085 ENSP00000377647
ENST00000460107
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000052917
View Gene Order
ENSBTAG00000016932
Not yet available
Cross-References
SwissProt Q9BQF6
TrEMBL
UniProt Splice Variant
Entrez Gene 57337
UniGene Hs.529551 Hs.605544
RefSeq NM_001077203 NM_001282801 NM_001282802 NM_001282803 NM_020654 XM_005247662 XM_006713713
HUGO HGNC:30402
OMIM 612846
CCDS CCDS2941 CCDS43121 CCDS63704 CCDS63705 CCDS63706
HPRD 07154
IMGT
EMBL AB051494 AC068764 AC073861 AC110994 AF199458 AF217504 AL136599 BC129988 BX537943
GenPept AAG09703 AAI29989 AAL25651 BAB21798 CAB66534 CAD97911
RNA Seq Atlas 57337

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca