InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MED7

Summary

InnateDB Gene

IDBG-55282.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MED7

Gene Name

mediator complex subunit 7

Synonyms

ARC34; CRSP33; CRSP9

Species

Homo sapiens

Ensembl Gene

ENSG00000155868

Encoded Proteins

IDBP-55284

mediator complex subunit 7

IDBP-380805

mediator complex subunit 7

IDBP-475196

mediator complex subunit 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:157137412-157159019

Strand

Reverse strand

Band

q33.3

Transcripts

ENST00000286317	ENSP00000286317
ENST00000420343	ENSP00000401046
ENST00000524289	ENSP00000430746

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	56 [view]
Protein-Protein	55 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0010467	gene expression
GO:0019827	stem cell maintenance

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005739	mitochondrion
GO:0016592	mediator complex
GO:0031965	nuclear membrane