Version 5.4
Homo sapiens Gene: IRF4
Summary
InnateDB Gene IDBG-55681.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IRF4
Gene Name interferon regulatory factor 4
Synonyms LSIRF; MUM1; NF-EM5
Species Homo sapiens
Ensembl Gene ENSG00000137265
Encoded Proteins
IDBP-55683
interferon regulatory factor 4
IDBP-593059
interferon regulatory factor 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 12566414
IRF4 participates in the regulation of lymphoid cell apoptosis by modulating the efficiency of the Fas-mediated death signal.
PMID 16272311
IRF4 provides a positive feedback signal for its own gene expression in dendritic cells (DCs) and the expression of IRF4 mRNA, but not of other IRFs, is specifically up-regulated during DC differentiation.
PMID 24670424
Following NOD2 activation, IRF4 interacts with MYD88, TRAF6, and RIPK2 and downregulates K63-linked polyubiquitinylation of RICK and TRAF6 leading to disruption of NFkB activation pathways.
Entrez Gene
Summary The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:391739-411447
Strand Forward strand
Band p25.3
Transcripts
ENST00000380956 ENSP00000370343
ENST00000468485
ENST00000495137
ENST00000493114 ENSP00000436094
ENST00000469834
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 82 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.
Experimentally validated
Total 82 [view]
Protein-Protein 37 [view]
Protein-DNA 45 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 35 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000975 regulatory region DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0016279 protein-lysine N-methyltransferase activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006479 protein methylation
GO:0018022 peptidyl-lysine methylation
GO:0019221 cytokine-mediated signaling pathway
GO:0034122 negative regulation of toll-like receptor signaling pathway
GO:0042110 T cell activation
GO:0042832 defense response to protozoan
GO:0043011 myeloid dendritic cell differentiation
GO:0043388 positive regulation of DNA binding
GO:0043966 histone H3 acetylation
GO:0043967 histone H4 acetylation
GO:0045082 positive regulation of interleukin-10 biosynthetic process
GO:0045086 positive regulation of interleukin-2 biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045368 positive regulation of interleukin-13 biosynthetic process
GO:0045404 positive regulation of interleukin-4 biosynthetic process
GO:0045622 regulation of T-helper cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0072540 T-helper 17 cell lineage commitment
Cellular Component
GO:0000788 nuclear nucleosome
GO:0005634 nucleus
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021356
View Gene Order
ENSBTAG00000002929
Not yet available
Pathways
NETPATH
REACTOME
REACT_25162
Interferon alpha/beta signaling pathway
REACT_25078
Interferon gamma signaling pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
il4_2pathway
IL4-mediated signaling events
Cross-References
SwissProt Q15306
TrEMBL F2Z3D5
UniProt Splice Variant
Entrez Gene 3662
UniGene Hs.604412 Hs.607866
RefSeq NM_001195286 NM_002460
HUGO HGNC:6119
OMIM 601900
CCDS CCDS4469
HPRD
IMGT
EMBL AL365272 AL512308 AL589962 BC015752 U52682 U63738
GenPept AAB37258 AAC50779 AAH15752 CAH71554 CAH72537
RNA Seq Atlas 3662

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca