InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ALOX15B

Summary

InnateDB Gene

IDBG-635491.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALOX15B

Gene Name

arachidonate 15-lipoxygenase B

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008779

Encoded Proteins

IDBP-687376

arachidonate 15-lipoxygenase, type B

IDBP-687378

arachidonate 15-lipoxygenase, type B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000179593:
This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:28306791-28315515

Strand

Forward strand

Band

Transcripts

ENSBTAT00000011570	ENSBTAP00000011570
ENSBTAT00000034910	ENSBTAP00000034794

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0016165	lipoxygenase activity
GO:0016491	oxidoreductase activity
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0036403	arachidonate 8(S)-lipoxygenase activity
GO:0046872	metal ion binding
GO:0050473	arachidonate 15-lipoxygenase activity
GO:0051213	dioxygenase activity

Biological Process

GO:0008285	negative regulation of cell proliferation
GO:0010744	positive regulation of macrophage derived foam cell differentiation
GO:0019369	arachidonic acid metabolic process
GO:0019372	lipoxygenase pathway
GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0043651	linoleic acid metabolic process
GO:0045618	positive regulation of keratinocyte differentiation
GO:0045786	negative regulation of cell cycle
GO:0045926	negative regulation of growth
GO:0055114	oxidation-reduction process
GO:0090197	positive regulation of chemokine secretion

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0019898	extrinsic component of membrane