Version 5.4
| Bos taurus Gene: GNG5 | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-637402.3 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | GNG5 | ||||||||||||||||||||||
| Gene Name | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | ||||||||||||||||||||||
| Synonyms | |||||||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||||||
| Ensembl Gene | ENSBTAG00000008122 | ||||||||||||||||||||||
| Encoded Proteins |
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174021:
G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary by Ahmad et al., 1995) [PubMed 7606925].[supplied by OMIM, Nov 2010] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 3:59783839-59791977 | ||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||
| Band | |||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Aquaporin-mediated transport pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
GABA B receptor activation pathway
Regulation of insulin secretion pathway
Glucagon-type ligand receptors pathway
Signaling by GPCR pathway
G protein gated Potassium channels pathway
GABA receptor activation pathway
Activation of GABAB receptors pathway
Inwardly rectifying K+ channels pathway
Integration of energy metabolism pathway
Transmission across Chemical Synapses pathway
Transmembrane transport of small molecules pathway
Activation of G protein gated Potassium channels pathway
Adrenaline,noradrenaline inhibits insulin secretion pathway
Signal Transduction pathway
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
GPCR ligand binding pathway
Neuronal System pathway
Metabolism pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Glucagon signaling in metabolic regulation pathway
Class B/2 (Secretin family receptors) pathway
Potassium Channels pathway
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| KEGG | |||||||||||||||||||||||
| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Prostacyclin signalling through prostacyclin receptor pathway
Platelet homeostasis pathway
ADP signalling through P2Y purinoceptor 12 pathway
ADP signalling through P2Y purinoceptor 1 pathway
Thromboxane signalling through TP receptor pathway
Thrombin signalling through proteinase activated receptors (PARs) pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
G alpha (q) signalling events pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G alpha (i) signalling events pathway
G beta:gamma signalling through PI3Kgamma pathway
G beta:gamma signalling through PLC beta pathway
G alpha (12/13) signalling events pathway
G alpha (s) signalling events pathway
G alpha (z) signalling events pathway
Glucagon-type ligand receptors pathway
Class B/2 (Secretin family receptors) pathway
G-protein activation pathway
Opioid Signalling pathway
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits pathway
GABA B receptor activation pathway
Presynaptic function of Kainate receptors pathway
Activation of G protein gated Potassium channels pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Adrenaline,noradrenaline inhibits insulin secretion pathway
Regulation of insulin secretion pathway
Glucagon signaling in metabolic regulation pathway
Integration of energy metabolism pathway
Transmembrane transport of small molecules pathway
Ca2+ pathway pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Neuronal System pathway
Signaling by GPCR pathway
GABA receptor activation pathway
G protein gated Potassium channels pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Activation of GABAB receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Inwardly rectifying K+ channels pathway
Activation of Kainate Receptors upon glutamate binding pathway
Potassium Channels pathway
Transmission across Chemical Synapses pathway
GPCR ligand binding pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Metabolism pathway
Signal amplification pathway
Aquaporin-mediated transport pathway
Hemostasis pathway
Inwardly rectifying K+ channels pathway
Glucagon-type ligand receptors pathway
Signaling by GPCR pathway
Glucagon signaling in metabolic regulation pathway
Class B/2 (Secretin family receptors) pathway
Integration of energy metabolism pathway
G protein gated Potassium channels pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Metabolism pathway
Activation of GABAB receptors pathway
Aquaporin-mediated transport pathway
Regulation of insulin secretion pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
Potassium Channels pathway
GABA B receptor activation pathway
GPCR ligand binding pathway
Transmembrane transport of small molecules pathway
GABA receptor activation pathway
Neuronal System pathway
Signal Transduction pathway
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits pathway
Transmission across Chemical Synapses pathway
Activation of G protein gated Potassium channels pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Adrenaline,noradrenaline inhibits insulin secretion pathway
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| KEGG |
Chemokine signaling pathway pathway
Chemokine signaling pathway pathway
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| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||
| SwissProt | P63217 | ||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | 287018 | ||||||||||||||||||||||
| UniGene | |||||||||||||||||||||||
| RefSeq | NM_174811 | ||||||||||||||||||||||
| HUGO | |||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | |||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| EMBL | BC102572 M95779 | ||||||||||||||||||||||
| GenPept | AAA30535 AAI02573 | ||||||||||||||||||||||
| RNA Seq Atlas | 287018 | ||||||||||||||||||||||