Version 5.4
Bos taurus Gene: CNKSR2
Summary
InnateDB Gene IDBG-638497.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNKSR2
Gene Name connector enhancer of kinase suppressor of ras 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000044202
Encoded Proteins
IDBP-690593
connector enhancer of kinase suppressor of Ras 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149970:
This gene encodes a multidomain protein that functions as a scaffold protein to mediate the mitogen-activated protein kinase pathways downstream from Ras. This gene product is induced by vitamin D and inhibits apoptosis in certain cancer cells. It may also play a role in ternary complex assembly of synaptic proteins at the postsynaptic membrane and coupling of signal transduction to membrane/cytoskeletal remodeling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:128890378-129117572
Strand Reverse strand
Band
Transcripts
ENSBTAT00000061509 ENSBTAP00000053655
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0009966 regulation of signal transduction
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000149970
View Gene Order
ENSMUSG00000025658
View Gene Order
Cross-References
SwissProt
TrEMBL F1N773
UniProt Splice Variant
Entrez Gene 534112
UniGene Bt.56543 Bt.62994
RefSeq NM_001206513 XM_003585380
HUGO HGNC:19701
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02074510 DAAA02074511 DAAA02074512
GenPept
RNA Seq Atlas 100851696 100852344 534112
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca