InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: NR5A1

Summary

InnateDB Gene

IDBG-638691.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NR5A1

Gene Name

Steroidogenic factor 1

Synonyms

SF-1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000009017

Encoded Proteins

IDBP-690778

Steroidogenic factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136931:
The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:95514365-95538847

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000011869

ENSBTAP00000011869

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008270	zinc ion binding
GO:0008289	lipid binding
GO:0019899	enzyme binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0001553	luteinization
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0008584	male gonad development
GO:0009888	tissue development
GO:0010259	multicellular organismal aging
GO:0022414	reproductive process
GO:0030154	cell differentiation
GO:0030325	adrenal gland development
GO:0042445	hormone metabolic process
GO:0043401	steroid hormone mediated signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051457	maintenance of protein location in nucleus
GO:2000020	positive regulation of male gonad development
GO:2000195	negative regulation of female gonad development