InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: NLRP3

Summary

InnateDB Gene

IDBG-645402.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NLRP3

Gene Name

NACHT, LRR and PYD domains-containing protein 3

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001273

Encoded Proteins

IDBP-698108

NACHT, LRR and PYD domains-containing protein 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25978411

[Homo sapiens] Influenza A virus non-structural protein 1, NS1, physically interacts with endogenous NLRP3 downregulating NLRP3 inflammasome activation as well as NF-kB, leading to a reduction in the levels of inflammatory cytokines.

PMID 25816776

[Homo sapiens] RNA cleavage products, catalyzed by RNASEL, bind to DHX33 to facilitate the formation of a complex with MAVS and NLRP3 during viral infection.

PMID 26610398

[Homo sapiens] H. pylori infection induces the expression and activation of components of NLRP3 inflammasomes in neutrophils and this activation is independent of a functional type IV secretion system, TLR2 and TLR4.

PMID 19362020

[Mus musculus] Nlrp3 mediated immune responses can be activated by RNA and mice lacking Nlrp3, or other inflammasome components, exhibit increased mortality and a reduced immune response after influenza virus exposure.

PMID 19362023

[Mus musculus] Nlrp3(-/-) mice exhibit increased morbidity after infection with a pathogenic influenza A virus correlating with decreased neutrophil and monocyte recruitment and reduced IL-1beta, IL-18, TNF-alpha, IL-6, KC, MIP2, and IFN-alpha production.

PMID 21278344

[Mus musculus] Nlrp3 is directly activated by certain antibiotics and plays an important role in the antibiotic-mediated secretion of Il1b. In the case of polymyxin B, Nlrp3 was also required for the neutrophil influx into the peritoneal cavity.

PMID 21289120

[Mus musculus] Nlrp3 inflammasome is essential for host defence against influenza and other RNA viruses (i.e. EMCV, VSV).

PMID 21385879

[Mus musculus] Nlrp3 recruits adaptor protein Pycard and Casp1 to form an Nlrp3 inflammasome complex in response to Varicella-Zoster Virus (VZV) infection.

PMID 21439959

[Mus musculus] Nlrp3 is a component of the inflammasome and is required for inflammation in acute pancreatitis.

PMID 21602824

[Mus musculus] Nlrp3 is necessary to illicit Il1b response specific to viable, but not heat-killed, E. coli infections.

PMID 22174673

[Mus musculus] Nlrp3 inflammasome plays a role in innate immune responses against mucosal Candida infection. Nlrp3 limits the severity of infection when present in either the hematopoietic or stromal compartments.

PMID 22295065

[Mus musculus] Nlrp3/Pycard inflammasome activation following human respiratory syncytial virus infection is dependent on the activation of Tlr2/Myd88/NF-kB and reactive oxygen species/potassium efflux. (Demonstrated in human)

PMID 22984081

[Mus musculus] MIR223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1beta production.

PMID 23809161

[Mus musculus] Potassium efflux is a common trigger of NLRP3 Inflammasome activation by bacterial toxins and particulate matter

PMID 24127597

[Mus musculus] Mitochondrial membrane potential is required for the association of Nlrp3 and Mfn2. Mfns2 is required for the activation of Nlrp3 inflammasomes.

PMID 24265316

[Mus musculus] 3, 4-methylenedioxy-β-nitrostyrene is a potent and specific inhibitor of the NLRP3 inflammasome.

PMID 24549849

[Mus musculus] Both Nlrp3 and Nlrp1a are important regulators of Toxoplasma proliferation and that IL18 signaling is required to mediate host resistance to acute toxoplasmosis.

PMID 24692555

[Mus musculus] Group B streptococcus induces Il1b, and activates the NLRP3 inflammasome by a mechanism that requires hemolysin-mediated lysosomal leakage, which enhances the interaction of bacterial RNA with NLRP3.

PMID 25689249

[Mus musculus] Activation of the Nlrp3 inflammasome is detrimental during leishmaniasis. Mice lacking the inflammasome components Nlrp3, Pycard, Casp1 exhibit defective Il1b and Il18 production at the infection site and are resistant to cutaneous Leishmania major infection.

PMID 26045547

[Mus musculus] Nlrp3 is a novel molecular target for melatonin which requires Rora to blunt the NFkB/ NLRP3 connection during sepsis.

PMID 27214553

[Mus musculus] Uropathogenic Escherichia coli protein TcpC attenuates activation of the Nlrp3 inflammasome by binding both Nlrp3 and Casp1.

PMID 26305961

[Mus musculus] Nlrp3 deficiency protects mice from the development of type 1 diabetes by suppressing Th1 responses and impairing T-cell migration to pancreatic islets through the down-regulation of chemokine expression (Ccl5, Cxcl10, Irf1) in islets.

PMID 26341399

[Mus musculus] Nlrp3 and Casp2 are required for endoplasmic reticulum stress-induced inflammation.

PMID 26416893

[Mus musculus] Impairment of the mitochondrial electron transport chain by rotenone primes Nlrp3 inflammasome activation upon costimulation with ATP.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162711:
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:42028059-42075814

Strand

Forward strand

Band

Transcripts

ENSBTAT00000001675

ENSBTAP00000001675

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0002674	negative regulation of acute inflammatory response
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954	inflammatory response
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032611	interleukin-1 beta production
GO:0032621	interleukin-18 production
GO:0042347	negative regulation of NF-kappaB import into nucleus
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044546	NLRP3 inflammasome complex assembly
GO:0050701	interleukin-1 secretion
GO:0050713	negative regulation of interleukin-1 beta secretion
GO:0050718	positive regulation of interleukin-1 beta secretion
GO:0050727	regulation of inflammatory response
GO:0050728	negative regulation of inflammatory response
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051607	defense response to virus
GO:0071222	cellular response to lipopolysaccharide