Version 5.4
Homo sapiens Gene: TRIM49
Summary
InnateDB Gene IDBG-67515.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIM49
Gene Name tripartite motif containing 49
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000168930
Encoded Proteins
IDBP-67517
tripartite motif containing 49
IDBP-601715
tripartite motif containing 49
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 23438823
TRIM49 was identified in a systematic screen for positive regulators of innate immune responses.
Entrez Gene
Summary The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This gene has been found to be preferentially expressed in testis. Related pseudogenes and gene duplicates have also been identified on chromosome 11. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:89797655-89808575
Strand Reverse strand
Band q14.3
Transcripts
ENST00000329758 ENSP00000327604
ENST00000532501 ENSP00000431618
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005622 intracellular
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL E9PK69
UniProt Splice Variant
Entrez Gene 57093
UniGene Hs.534218
RefSeq NM_020358
HUGO HGNC:13431
OMIM 606124
CCDS CCDS8287
HPRD 05840
IMGT
EMBL AP004833
GenPept
RNA Seq Atlas 57093

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca