InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GRIK4

Summary

InnateDB Gene

IDBG-74672.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRIK4

Gene Name

glutamate receptor, ionotropic, kainate 4

Synonyms

EAA1; GluK4; GRIK; KA1

Species

Homo sapiens

Ensembl Gene

ENSG00000149403

Encoded Proteins

IDBP-384125

glutamate receptor, ionotropic, kainate 4

IDBP-599023

glutamate receptor, ionotropic, kainate 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. [provided by RefSeq, Jul 2008]
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:120511759-120988904

Strand

Forward strand

Band

q23.3

Transcripts

ENST00000438375	ENSP00000404063
ENST00000527524	ENSP00000435648
ENST00000533291
ENST00000526536
ENST00000527130
ENST00000530172

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004970	ionotropic glutamate receptor activity
GO:0005215	transporter activity
GO:0005234	extracellular-glutamate-gated ion channel activity
GO:0005515	protein binding
GO:0015277	kainate selective glutamate receptor activity

Biological Process

GO:0006810	transport
GO:0007215	glutamate receptor signaling pathway
GO:0007268	synaptic transmission
GO:0031960	response to corticosteroid
GO:0034220	ion transmembrane transport
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0030054	cell junction
GO:0030424	axon
GO:0030425	dendrite
GO:0032983	kainate selective glutamate receptor complex
GO:0042734	presynaptic membrane
GO:0043195	terminal bouton
GO:0043204	perikaryon
GO:0045202	synapse
GO:0045211	postsynaptic membrane

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000032017

View Gene Order

Pathways

NETPATH

REACTOME

REACT_13685

Neuronal System pathway

REACT_21322

Ionotropic activity of Kainate Receptors pathway

REACT_21312

Activation of Kainate Receptors upon glutamate binding pathway

REACT_13477

Transmission across Chemical Synapses pathway

REACT_21346

Activation of Ca-permeable Kainate Receptor pathway

REACT_15370

Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.568901 Hs.645915

RefSeq

NM_001282470 NM_001282473 NM_014619

HUGO

OMIM

CCDS

CCDS8433

HPRD

02613

IMGT

EMBL

GenPept

RNA Seq Atlas