Homo sapiens Gene: RHOBTB1
Summary
InnateDB Gene IDBG-75407.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RHOBTB1
Gene Name Rho-related BTB domain containing 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000072422
Encoded Proteins
Rho-related BTB domain containing 1
Rho-related BTB domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:60869438-61001440
Strand Reverse strand
Band q21.2
Transcripts
ENST00000357917 ENSP00000350595
ENST00000337910 ENSP00000338671
ENST00000496237
ENST00000461910
ENST00000490827
ENST00000483488
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Rho GTPase cycle pathway
Signaling by Rho GTPases pathway
Signal Transduction pathway
KEGG
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt O94844
TrEMBL A0A024QZL4 Q567T3
UniProt Splice Variant
Entrez Gene 9886
UniGene Hs.624978 Hs.733423 Hs.741292
RefSeq XM_006718084 XM_006718085 NM_001242359 NM_014836 XM_006718088
HUGO HGNC:18738
OMIM 607351
CCDS CCDS7261
HPRD 06299
IMGT
EMBL AB018283 AK075129 BC032848 BC041791 BC093035 CH471083
GenPept AAH32848 AAH41791 AAH93035 BAA34460 BAC11421 EAW54213 EAW54215 EAW54216 EAW54217
RNA Seq Atlas 9886