Homo sapiens Gene: TUSC3
Summary
InnateDB Gene IDBG-8156.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TUSC3
Gene Name tumor suppressor candidate 3
Synonyms D8S1992; M33; MRT22; MRT7; N33; OST3A
Species Homo sapiens
Ensembl Gene ENSG00000104723
Encoded Proteins
tumor suppressor candidate 3
tumor suppressor candidate 3
tumor suppressor candidate 3
tumor suppressor candidate 3
tumor suppressor candidate 3
tumor suppressor candidate 3
tumor suppressor candidate 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a candidate tumor suppressor gene. It is located within a homozygously deleted region of a metastatic prostate cancer. The gene is expressed in most nonlymphoid human tissues including prostate, lung, liver, and colon. Expression was also detected in many epithelial tumor cell lines. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:15417215-15766649
Strand Forward strand
Band p22
Transcripts
ENST00000382020 ENSP00000371450
ENST00000503191
ENST00000515859 ENSP00000420829
ENST00000506802 ENSP00000425777
ENST00000510836 ENSP00000426973
ENST00000509380 ENSP00000423426
ENST00000503731 ENSP00000424544
ENST00000511783 ENSP00000426880
ENST00000507400
ENST00000509177
ENST00000508446
ENST00000507316
ENST00000511342
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity
GO:0015095 magnesium ion transmembrane transporter activity
Biological Process
GO:0006487 protein N-linked glycosylation
GO:0015693 magnesium ion transport
GO:0018279 protein N-linked glycosylation via asparagine
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0045454 cell redox homeostasis
GO:0050890 cognition
Cellular Component
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
GO:0005887 integral component of plasma membrane
GO:0008250 oligosaccharyltransferase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Asparagine N-linked glycosylation pathway
Post-translational protein modification pathway
Metabolism of proteins pathway
KEGG
N-Glycan biosynthesis pathway
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D6RDV0
UniProt Splice Variant
Entrez Gene 7991
UniGene Hs.613699 Hs.743610
RefSeq NM_006765 NM_178234 XM_005273647
HUGO HGNC:30242
OMIM 601385
CCDS CCDS5993 CCDS5994
HPRD 03228
IMGT
EMBL AC010656 AC019292 AC091559 AC100850
GenPept
RNA Seq Atlas 7991