Version 5.4
Homo sapiens Gene: AGFG1
Summary
InnateDB Gene IDBG-82607.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AGFG1
Gene Name ArfGAP with FG repeats 1
Synonyms HRB; RAB; RIP
Species Homo sapiens
Ensembl Gene ENSG00000173744
Encoded Proteins
IDBP-82609
ArfGAP with FG repeats 1
IDBP-82611
ArfGAP with FG repeats 1
IDBP-292950
ArfGAP with FG repeats 1
IDBP-292955
ArfGAP with FG repeats 1
IDBP-292957
ArfGAP with FG repeats 1
IDBP-389180
ArfGAP with FG repeats 1
IDBP-389181
ArfGAP with FG repeats 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. The encoded protein binds the activation domain of the human immunodeficiency virus Rev protein when Rev is assembled onto its RNA target, and is required for the nuclear export of Rev-directed RNAs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:227472152-227561214
Strand Forward strand
Band q36.3
Transcripts
ENST00000310078 ENSP00000312059
ENST00000373671 ENSP00000362775
ENST00000409315 ENSP00000387154
ENST00000409171 ENSP00000387218
ENST00000409979 ENSP00000387282
ENST00000456594 ENSP00000405429
ENST00000458212 ENSP00000396469
ENST00000486932
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
Biological Process
GO:0001675 acrosome assembly
GO:0006406 mRNA export from nucleus
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0007289 spermatid nucleus differentiation
GO:0030154 cell differentiation
GO:0032312 regulation of ARF GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0045087 innate immune response
GO:0045109 intermediate filament organization
Cellular Component
GO:0005643 nuclear pore
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0042995 cell projection
GO:0043025 neuronal cell body
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026159
View Gene Order
ENSBTAG00000021323
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.595484 Hs.707245
RefSeq NM_001135187 NM_001135188 NM_001135189 NM_004504
HUGO
OMIM
CCDS CCDS2467 CCDS46533 CCDS46534 CCDS46535
HPRD 02918
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca