Version 5.4
Homo sapiens Gene: KCNK18
Summary
InnateDB Gene IDBG-90792.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNK18
Gene Name potassium channel, subfamily K, member 18
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000186795
Encoded Proteins
IDBP-90794
potassium channel, subfamily K, member 18
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains and the encoded protein functions as an outward rectifying potassium channel. A mutation in this gene has been found to be associated with migraine with aura.[provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:117197489-117210299
Strand Forward strand
Band q25.3
Transcripts
ENST00000334549 ENSP00000334650
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005267 potassium channel activity
GO:0005515 protein binding
GO:0015269 calcium-activated potassium channel activity
GO:0015271 outward rectifier potassium channel activity
Biological Process
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0071435 potassium ion export
GO:0071467 cellular response to pH
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040901
View Gene Order
ENSBTAG00000015062
Not yet available
Pathways
NETPATH
REACTOME
REACT_75801
TWIK-related spinal cord K+ channel (TRESK) pathway
REACT_75897
Tandem pore domain potassium channels pathway
REACT_13685
Neuronal System pathway
REACT_75908
Potassium Channels pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.449650
RefSeq NM_181840
HUGO
OMIM
CCDS CCDS7598
HPRD 17173
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca