Version 5.4
Homo sapiens Gene: PLEKHG3
Summary
InnateDB Gene IDBG-9221.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLEKHG3
Gene Name pleckstrin homology domain containing, family G (with RhoGef domain) member 3
Synonyms ARHGEF43; KIAA0599
Species Homo sapiens
Ensembl Gene ENSG00000126822
Encoded Proteins
IDBP-9223
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
IDBP-241055
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
IDBP-604262
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
IDBP-604263
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
IDBP-604254
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
IDBP-604257
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
IDBP-604259
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 14:64704102-64750247
Strand Forward strand
Band q23.3
Transcripts
ENST00000247226 ENSP00000247226
ENST00000394691 ENSP00000378183
ENST00000490180
ENST00000471182 ENSP00000450945
ENST00000484731 ENSP00000450973
ENST00000492928
ENST00000555982 ENSP00000450501
ENST00000554088 ENSP00000450880
ENST00000554499 ENSP00000451256
ENST00000556801
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
Biological Process
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000052609
View Gene Order
ENSBTAG00000001551
Not yet available
Cross-References
SwissProt A1L390
TrEMBL G3V278 G3V2V2 G3V311 G3V3I3
UniProt Splice Variant
Entrez Gene 26030
UniGene Hs.509637 Hs.689614
RefSeq NM_015549
HUGO HGNC:20364
OMIM
CCDS CCDS32098
HPRD
IMGT
EMBL AB011171 AK074169 AL121774 BC004298 BC011891 BC063554 BC073907 BC129952 BC129953 BX248779
GenPept AAH04298 AAH11891 AAH63554 AAH73907 AAI29953 AAI29954 BAA25525 BAB84995 CAD66586
RNA Seq Atlas 26030

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca