Version 5.4
Homo sapiens Gene: CDK19
Summary
InnateDB Gene IDBG-95275.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDK19
Gene Name cyclin-dependent kinase 19
Synonyms bA346C16.3; CDC2L6; CDK11
Species Homo sapiens
Ensembl Gene ENSG00000155111
Encoded Proteins
IDBP-95277
cyclin-dependent kinase 19
IDBP-95279
cyclin-dependent kinase 19
IDBP-386053
cyclin-dependent kinase 19
IDBP-386054
cyclin-dependent kinase 19
IDBP-597676
cyclin-dependent kinase 19
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is one of the components of the Mediator coactivator complex. The Mediator complex is a multiprotein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. [provided by RefSeq, Jul 2008]
This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:110609978-110815958
Strand Reverse strand
Band q21
Transcripts
ENST00000323817 ENSP00000317665
ENST00000368911 ENSP00000357907
ENST00000413605 ENSP00000410604
ENST00000457688 ENSP00000415621
ENST00000463016 ENSP00000434476
ENST00000460913
ENST00000497709
ENST00000468997
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 65 [view]
Protein-Protein 64 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0051726 regulation of cell cycle
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038481
View Gene Order
ENSBTAG00000007288
Not yet available
Pathways
NETPATH
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_111045
Developmental Biology pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 23097
UniGene Hs.584867 Hs.594991 Hs.607181 Hs.731574 Hs.732143 Hs.734468
RefSeq NM_001300960 NM_001300963 NM_001300964 NM_015076 XM_005266870 XM_005266871 XM_005266872 XM_005266873 XM_006715402
HUGO HGNC:19338
OMIM 614720
CCDS CCDS5085 CCDS75503
HPRD 07627
IMGT
EMBL
GenPept
RNA Seq Atlas 23097

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca