Version 5.4
Homo sapiens Protein: CEP192
Summary
InnateDB Protein IDBP-1212.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CEP192
Protein Name centrosomal protein 192kDa
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000317156
InnateDB Gene IDBG-1210 (CEP192)
Protein Structure
UniProt Annotation
Function Required for mitotic centrosome and spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication. {ECO:0000269PubMed:17980596, ECO:0000269PubMed:18207742}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269PubMed:14654843, ECO:0000269PubMed:17980596, ECO:0000269PubMed:18207742}. Note=Pericentriolar location in mitotic centrosomes.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019902 phosphatase binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0010923 negative regulation of phosphatase activity
GO:0051225 spindle assembly
GO:0051298 centrosome duplication
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005814 centriole
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TEP8
PhosphoSite PhosphoSite-
TrEMBL C9JT09
UniProt Splice Variant
Entrez Gene 55125
UniGene
RefSeq XP_005258166
HUGO HGNC:25515
OMIM
CCDS
HPRD 10855
IMGT
EMBL AF318363 AK001214 AK074074 AL136818 AP001357 AP002449
GenPept AAL55870 BAA91559 BAB84900 CAB66752

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca