InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mup20

Summary

InnateDB Protein

IDBP-128152.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mup20

Protein Name

major urinary protein 20

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000073667

InnateDB Gene

IDBG-266600 (Mup20)

Protein Structure

UniProt Annotation

Function

Male pheromone which stimulates female sexual attraction to male urinary scent and promotes a strong learned attraction to the airborne urinary odor of an individual male. Promotes male aggressive behavior. Binds most of the male pheromone, 2-sec- butyl-4,5-dihydrothiazole, in urine. {ECO:0000269PubMed:15934926, ECO:0000269PubMed:18064011, ECO:0000269PubMed:20525243}.

Subcellular Localization

Secreted {ECO:0000269PubMed:15934926, ECO:0000269PubMed:20525243}.

Disease Associations

Tissue Specificity

Detected in urine of males but absent from female urine (at protein level). {ECO:0000269PubMed:15934926, ECO:0000269PubMed:20525243}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000772	mating pheromone activity
GO:0005009	insulin-activated receptor activity
GO:0005215	transporter activity
GO:0005550	pheromone binding
GO:0036094	small molecule binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006810	transport
GO:0008286	insulin receptor signaling pathway
GO:0008355	olfactory learning
GO:0009060	aerobic respiration
GO:0010628	positive regulation of gene expression
GO:0010888	negative regulation of lipid storage
GO:0010907	positive regulation of glucose metabolic process
GO:0031649	heat generation
GO:0042593	glucose homeostasis
GO:0045475	locomotor rhythm
GO:0045721	negative regulation of gluconeogenesis
GO:0045834	positive regulation of lipid metabolic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051055	negative regulation of lipid biosynthetic process
GO:0051897	positive regulation of protein kinase B signaling
GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070584	mitochondrion morphogenesis
GO:0071396	cellular response to lipid

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:3651981

InterPro

IPR000566 Lipocalin/cytosolic fatty-acid binding domain
IPR002345 Lipocalin
IPR002447 Beta-lactoglobulin
IPR002448 Odour-binding protein
IPR002450 von Ebner\'s gland protein/ Bos/Can allergen
IPR002968 Alpha-1-microglobulin
IPR002971 Major urinary protein
IPR002972 Prostaglandin D synthase
IPR003087 Neutrophil gelatinase-associated lipocalin
IPR011038 Calycin-like

PFAM

PF00061
PF08212

PRINTS