InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Snap29

Summary

InnateDB Protein

IDBP-138866.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Snap29

Protein Name

synaptosomal-associated protein 29

Synonyms

1300018G05Rik; AI891940; AU020222; BB131856; Gs32;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023449

InnateDB Gene

IDBG-138864 (Snap29)

Protein Structure

UniProt Annotation

Function

SNAREs, Soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Probably involved in multiple membrane trafficking steps (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Note=Appears to be mostly membrane-bound, probably via interaction with syntaxins, but a significant portion is cytoplasmic. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000046	autophagic vacuole fusion
GO:0015031	protein transport

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0030054	cell junction
GO:0031201	SNARE complex
GO:0043005	neuron projection
GO:0045202	synapse

Protein Structure and Domains

PDB ID

MGI:1914724

InterPro

IPR000727 Target SNARE coiled-coil domain
IPR000928 SNAP-25

PFAM

PF05739
PF00835

PRINTS

PIRSF

SMART

SM00397

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9ERB0

PhosphoSite

PhosphoSite-Q9ERB0

TrEMBL

UniProt Splice Variant

Entrez Gene

67474

UniGene

Mm.470741

RefSeq

NP_075837

MGI ID

MGI Symbol

Snap29

OMIM

CCDS

CCDS28001

HPRD

IMGT

EMBL

AK005042 AK007065 AK039203 AK147845 AY008722 BC030066

GenPept

AAG32076 AAH30066 BAB23769 BAB24850 BAC30277 BAE28177