InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ddx25

Summary

InnateDB Protein

IDBP-148668.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ddx25

Protein Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 25

Synonyms

AW047046; GRTH;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034612

InnateDB Gene

IDBG-148666 (Ddx25)

Protein Structure

UniProt Annotation

Function

ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development. {ECO:0000269PubMed:16968703}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Detected in both cytoplasm and nucleus of testicular cells. Also detected in chromatoid bodies of round spermatids.

Disease Associations

Tissue Specificity

Isoform 1 is expressed in germ cells. Isoform 2 is expressed in Leydig cells and in round spermatids of adult testis upon gonadotropin stimulation. {ECO:0000269Ref.2}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0004004	ATP-dependent RNA helicase activity
GO:0004386	helicase activity
GO:0005524	ATP binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006406	mRNA export from nucleus
GO:0006417	regulation of translation
GO:0007275	multicellular organismal development
GO:0007286	spermatid development

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0033391	chromatoid body

Protein Structure and Domains

PDB ID

MGI:1353582

InterPro

IPR001650 Helicase, C-terminal
IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014014 RNA helicase, DEAD-box type, Q motif
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00270

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9QY15