InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Serinc1

Summary

InnateDB Protein

IDBP-152418.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Serinc1

Protein Name

serine incorporator 1

Synonyms

1500011D18Rik; AI315070; AIGP-2; mKIAA1253; Tde1l; Tde2; TMS-2; Tms2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020027

InnateDB Gene

IDBG-152416 (Serinc1)

Protein Structure

UniProt Annotation

Function

Enhances the incorporation of serine into phosphatidylserine and sphingolipids. {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in the neuronal populations such as Purkinje cells in the cerebellum, brainstem and spinal motor neurons, locus coeruleus and raphe nuclei.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015194	L-serine transmembrane transporter activity

Biological Process

GO:0006658	phosphatidylserine metabolic process
GO:0006665	sphingolipid metabolic process
GO:0008654	phospholipid biosynthetic process
GO:0015825	L-serine transport
GO:0051347	positive regulation of transferase activity

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome