InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Evc

Summary

InnateDB Protein

IDBP-158982.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Evc

Protein Name

Ellis van Creveld gene homolog (human)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031005

InnateDB Gene

IDBG-158980 (Evc)

Protein Structure

UniProt Annotation

Function

Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and skeletal development. {ECO:0000269PubMed:17660199}.

Subcellular Localization

Cell membrane; Single-pass membrane protein. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium. Cell projection, cilium membrane. Note=EVC2 is required for the localization of EVC at the base of primary cilia.

Disease Associations

Tissue Specificity

Expressed in the developing skeleton and the orofacial region. Expression is general to all the cartilaginous components of the skeleton, including the chondrocranium, the vertebrae, the rib cage, and the axial skeleton by day E15.5. {ECO:0000269PubMed:17660199}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0003416	endochondral bone growth
GO:0007224	smoothened signaling pathway
GO:0045880	positive regulation of smoothened signaling pathway
GO:0051216	cartilage development