InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cyp2a4

Summary

InnateDB Protein

IDBP-159095.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyp2a4

Protein Name

cytochrome P450, family 2, subfamily a, polypeptide 4

Synonyms

AI893559; Cyp15a1; D7Ucla4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000096254

InnateDB Gene

IDBG-159093 (Cyp2a4)

Protein Structure

UniProt Annotation

Function

Highly active in the 15-alpha-hydroxylation of testosterone. Also active in the 15-alpha-hydroxylation of progesterone and androstenedione. Little or no activity on corticosterone, pregnenolone, dehydroepiandrosterone, estradiol or estriol.

Subcellular Localization

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Kidney and lung. Expressed in liver, with a strong circadian rhythmicity. Circadian expression is regulated by DBP. {ECO:0000269PubMed:10490589}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0070330	aromatase activity

Biological Process

GO:0035634	response to stilbenoid
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005789

endoplasmic reticulum membrane

Protein Structure and Domains

PDB ID

MGI:88596

InterPro

IPR001128 Cytochrome P450
IPR002397 Cytochrome P450, B-class
IPR002401 Cytochrome P450, E-class, group I
IPR002403 Cytochrome P450, E-class, group IV
IPR008067 Cytochrome P450, E-class, group I, CYP2A-like

PFAM

PF00067

PRINTS

PR00385
PR00359
PR00463
PR00465
PR01684

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P15392