Version 5.4
Mus musculus Protein: Gtf2a1
Summary
InnateDB Protein IDBP-161446.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gtf2a1
Protein Name general transcription factor II A, 1
Synonyms 6330549H03Rik; AA536742; AA959775; AW060250; Tfiia1; TfIIAa/b;
Species Mus musculus
Ensembl Protein ENSMUSP00000021345
InnateDB Gene IDBG-161442 (Gtf2a1)
Protein Structure
UniProt Annotation
Function TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in pachytene spermatocytes and spermatids. {ECO:0000269PubMed:11159353}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0005515 protein binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005672 transcription factor TFIIA complex
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1933277
InterPro IPR004855 Transcription factor IIA, alpha/beta subunit
IPR009083 Transcription factor IIA, helical
IPR009088 Transcription factor IIA, beta-barrel
PFAM PF03153
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99PM3
PhosphoSite PhosphoSite-
TrEMBL Q149E9
UniProt Splice Variant
Entrez Gene 83602
UniGene Mm.275728
RefSeq NP_113568
MGI ID
MGI Symbol Gtf2a1
OMIM
CCDS CCDS26089
HPRD
IMGT
EMBL AC154709 AC159822 AF250834 AK048711 BC117829 BC117830
GenPept AAG50431 AAI17830 AAI17831 BAC33430

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca