Version 5.4
Mus musculus Protein: Tff1
Summary
InnateDB Protein IDBP-163848.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tff1
Protein Name trefoil factor 1
Synonyms Bcei; PS2;
Species Mus musculus
Ensembl Protein ENSMUSP00000024831
InnateDB Gene IDBG-163846 (Tff1)
Protein Structure
UniProt Annotation
Function Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Strong expression found in normal gastric mucosa. Not detected in the small or large intestine nor in normal mammary gland.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0008285 negative regulation of cell proliferation
GO:0009611 response to wounding
GO:0010039 response to iron ion
GO:0030154 cell differentiation
GO:0030277 maintenance of gastrointestinal epithelium
GO:0032355 response to estradiol
GO:0035902 response to immobilization stress
GO:0043434 response to peptide hormone
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:88135
InterPro IPR000519 P-type trefoil
IPR017994 P-type trefoil, chordata
PFAM PF00088
PRINTS PR00680
PIRSF
SMART SM00018
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q08423
PhosphoSite PhosphoSite-
TrEMBL Q149Y8
UniProt Splice Variant
Entrez Gene 21784
UniGene Mm.2854
RefSeq NP_033388
MGI ID
MGI Symbol Tff1
OMIM
CCDS CCDS37546
HPRD
IMGT
EMBL AJ271002 AK008625 AK008809 AK008873 AK010179 AK131896 AK160174 BC117054 BC117056 CH466640 Z21858
GenPept AAI17055 AAI17057 BAB25787 BAB25907 BAB25943 BAB26751 BAE20857 BAE35673 CAA79913 CAB65750 EDL40368

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca