InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rnf130

Summary

InnateDB Protein

IDBP-167983.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rnf130

Protein Name

ring finger protein 130

Synonyms

G1rp; G1RZFP; GOLIATH; GP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099837

InnateDB Gene

IDBG-167981 (Rnf130)

Protein Structure

UniProt Annotation

Function

Acts as an E3 ubiquitin-protein ligase (By similarity). May have a role during the programmed cell death of hematopoietic cells. {ECO:0000250, ECO:0000269PubMed:10806348}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Expression is highest in liver, with lesser amounts in the lung, spleen, brain, heart, kidney and testis. {ECO:0000269PubMed:10806348}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0006915	apoptotic process
GO:0012501	programmed cell death
GO:0016567	protein ubiquitination

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1891717

InterPro

IPR001841 Zinc finger, RING-type
IPR003137 Protease-associated domain, PA
IPR018957 Zinc finger, C3HC4 RING-type

PFAM

PF13639
PF14634
PF02225
PF00097

PRINTS

PIRSF

SMART

SM00184

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8VEM1

PhosphoSite

PhosphoSite-Q8VEM1

TrEMBL

UniProt Splice Variant

Entrez Gene

59044

UniGene

RefSeq

NP_067515

MGI ID

MGI Symbol

Rnf130

OMIM

CCDS

CCDS24626

HPRD

IMGT

EMBL

AF171875 AL627187 AL645913 BC018199 BC048901

GenPept

AAF05310 AAH18199 AAH48901 CAI24372 CAI25115