InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nlrp3

Summary

InnateDB Protein

IDBP-178926.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nlrp3

Protein Name

NLR family, pyrin domain containing 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000078440

InnateDB Gene

IDBG-178924 (Nlrp3)

Protein Structure

UniProt Annotation

Function

May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA (By similarity). Activates caspase-1 as part of the NALP3 inflammasome complex in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18. {ECO:0000250, ECO:0000269PubMed:16407888, ECO:0000269PubMed:16407890, ECO:0000269PubMed:16546100, ECO:0000269PubMed:17008311}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:14688236}.

Disease Associations

Tissue Specificity

Widely expressed with high levels in peripheral blood leukocytes. Not detected in thymus. {ECO:0000269PubMed:15302403, ECO:0000269PubMed:16546100}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0002674	negative regulation of acute inflammatory response
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954	inflammatory response
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032611	interleukin-1 beta production
GO:0032621	interleukin-18 production
GO:0042347	negative regulation of NF-kappaB import into nucleus
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044546	NLRP3 inflammasome complex assembly
GO:0045087	innate immune response (InnateDB)
GO:0050701	interleukin-1 secretion
GO:0050713	negative regulation of interleukin-1 beta secretion
GO:0050718	positive regulation of interleukin-1 beta secretion
GO:0050727	regulation of inflammatory response
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051607	defense response to virus
GO:0071222	cellular response to lipopolysaccharide

Cellular Component

GO:0005829	cytosol
GO:0072559	NLRP3 inflammasome complex

Protein Structure and Domains

PDB ID

MGI:2653833

InterPro

IPR003590 Leucine-rich repeat, ribonuclease inhibitor subtype
IPR004020 DAPIN domain
IPR007111 NACHT nucleoside triphosphatase
IPR011029 Death-like domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF02758

PRINTS

PIRSF

SMART

SM00368

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8R4B8