InnateDB Protein
|
IDBP-182040.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Gpc1
|
Protein Name
|
glypican 1
|
Synonyms
|
AI462976;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000047199
|
InnateDB Gene
|
IDBG-182038 (Gpc1)
|
Protein Structure
|
|
Function |
Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. Binds Cu(2+) or Zn(2+) ions. {ECO:0000250, ECO:0000269PubMed:19732411, ECO:0000269PubMed:19936054, ECO:0000269PubMed:20100867, ECO:0000269PubMed:21996748}.
|
Subcellular Localization |
Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Endosome. Note=S-nitrosylated form recycled in endosomes. Localizes to CAV1-containing vesicles close to the cell surface. Cleavage of heparan sulfate side chains takes place mainly in late endosomes. Associates with both forms of PRNP in lipid rafts. Colocalizes with APP in perinuclear compartments and with CP in intracellular compartments. Associates with fibrillar APP Abeta peptides in lipid rafts in Alzheimer disease brains.Secreted glypican-1: Secreted, extracellular space.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
|
Protein-Protein |
4
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
5 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0014037
|
Schwann cell differentiation
|
GO:0030200
|
heparan sulfate proteoglycan catabolic process
|
GO:0032288
|
myelin assembly
|
GO:0040037
|
negative regulation of fibroblast growth factor receptor signaling pathway
|
GO:2001016
|
positive regulation of skeletal muscle cell differentiation
|
|
Cellular Component |
|
PDB ID |
MGI:1194891
|
InterPro |
IPR001863
Glypican
|
PFAM |
PF01153
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9QZF2
|
PhosphoSite |
PhosphoSite-Q9QZF2
|
TrEMBL |
Q3U379
|
UniProt Splice Variant |
|
Entrez Gene |
14733
|
UniGene |
Mm.490321
|
RefSeq |
NP_057905
|
MGI ID |
|
MGI Symbol |
Gpc1
|
OMIM |
|
CCDS |
CCDS15177
|
HPRD |
|
IMGT |
|
EMBL |
AF185613
AK154899
BC062902
CH466520
|
GenPept |
AAD56243
AAH62902
BAE32910
EDL39994
|
|
|