InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: B9d1

Summary

InnateDB Protein

IDBP-183274.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

B9d1

Protein Name

B9 protein domain 1

Synonyms

AW045994; B9; Eppb9;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099717

InnateDB Gene

IDBG-183272 (B9d1)

Protein Structure

UniProt Annotation

Function

Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling. {ECO:0000269PubMed:21725307, ECO:0000269PubMed:21763481, ECO:0000269PubMed:22179047}.

Subcellular Localization

Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269PubMed:21725307, ECO:0000269PubMed:22179047}. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008158	hedgehog receptor activity

Biological Process

GO:0001701	in utero embryonic development
GO:0001944	vasculature development
GO:0007224	smoothened signaling pathway
GO:0032880	regulation of protein localization
GO:0042384	cilium assembly
GO:0042733	embryonic digit morphogenesis
GO:0043010	camera-type eye development
GO:0060271	cilium morphogenesis
GO:0060563	neuroepithelial cell differentiation

Cellular Component

GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0016020	membrane
GO:0035869	ciliary transition zone
GO:0036038	TCTN-B9D complex
GO:0036064	ciliary basal body

Protein Structure and Domains

PDB ID

MGI:1351471

InterPro

IPR010796 B9 domain

PFAM

PF07162

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9R1S0

PhosphoSite

PhosphoSite-Q9R1S0

TrEMBL

UniProt Splice Variant

Entrez Gene

27078

UniGene

RefSeq

NP_038745

MGI ID

MGI Symbol

B9d1

OMIM

CCDS

CCDS24815

HPRD

IMGT

EMBL

AB030483 AK003038 AK010355 AK131701 AL604029 BC008113

GenPept

AAH08113 BAA82643 BAB22525 BAB26875 BAE20767 CAI24186