InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Oxct2b

Summary

InnateDB Protein

IDBP-184916.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Oxct2b

Protein Name

3-oxoacid CoA transferase 2B

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099708

InnateDB Gene

IDBG-184914 (Oxct2b)

Protein Structure

UniProt Annotation

Function

Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). Probably play and important roles in the energy metabolism of spermatozoa. {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Testis specific. Expressed in late spermatids. Accumulates during spermiogenesis. Also detected in the midpiece of spermatozoa. {ECO:0000269PubMed:11090426}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008260	3-oxoacid CoA-transferase activity
GO:0008410	CoA-transferase activity

Biological Process

GO:0006091	generation of precursor metabolites and energy
GO:0008152	metabolic process
GO:0046952	ketone body catabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0031514	motile cilium

Protein Structure and Domains

PDB ID

MGI:2664115

InterPro

IPR004165 Coenzyme A transferase family I
IPR012791 3-oxoacid CoA-transferase, subunit B
IPR012792 3-oxoacid CoA-transferase, subunit A
IPR014388 3-oxoacid CoA-transferase

PFAM

PF01144

PRINTS

PIRSF

PIRSF000858

SMART

SM00882

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt