Version 5.4
Mus musculus Protein: Clec4e
Summary
InnateDB Protein IDBP-186404.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Clec4e
Protein Name C-type lectin domain family 4, member e
Synonyms C86253; Clecsf9; Mincle;
Species Mus musculus
Ensembl Protein ENSMUSP00000032239
InnateDB Gene IDBG-186402 (Clec4e)
Protein Structure
UniProt Annotation
Function C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B. {ECO:0000269PubMed:10528209, ECO:0000269PubMed:18509109, ECO:0000269PubMed:19171887}.
Subcellular Localization Membrane {ECO:0000305PubMed:10528209}; Single-pass type II membrane protein {ECO:0000305PubMed:10528209}.
Disease Associations
Tissue Specificity Expressions were observed in peritoneal macrophage, macrophage cell line RAW 264.7, and myeloblastic leukemia cell line M1 following inflammatory stimuli. {ECO:0000269PubMed:10528209}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 3 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
GO:0006955 immune response
GO:0045087 innate immune response (InnateDB)
GO:0050715 positive regulation of cytokine secretion
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1861232
InterPro IPR001304 C-type lectin
IPR002353 Type-2 ice-structuring protein
IPR016187 C-type lectin fold
PFAM PF00059
PRINTS PR00356
PIRSF
SMART SM00034
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9R0Q8
PhosphoSite PhosphoSite-
TrEMBL Q4FK29
UniProt Splice Variant
Entrez Gene 56619
UniGene Mm.416157
RefSeq NP_064332
MGI ID
MGI Symbol Clec4e
OMIM
CCDS CCDS20514
HPRD
IMGT
EMBL AB024717 AK150528 AK150899 AK151101 AK151912 AK153008 AK153308 AK156437 AK170698 AK171103 BC003218 CH466523 CT010223
GenPept AAH03218 BAA83754 BAE29637 BAE29944 BAE30111 BAE30792 BAE31647 BAE31889 BAE33711 BAE41962 BAE42251 CAJ18431 EDK99715

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca