InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ranbp10

Summary

InnateDB Protein

IDBP-188583.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ranbp10

Protein Name

RAN binding protein 10

Synonyms

4432417N03Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040045

InnateDB Gene

IDBG-188581 (Ranbp10)

Protein Structure

UniProt Annotation

Function

May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (By similarity). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function. {ECO:0000250, ECO:0000269PubMed:18347012, ECO:0000269PubMed:19801445}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:18347012}. Nucleus {ECO:0000269PubMed:18347012}. Note=Predominantly cytoplasmic. Associates with cytoplasmic microtubules in mature megakaryocytes and platelets.

Disease Associations

Tissue Specificity

Expressed at highest levels in spleen and liver. Expressed in megakaryocytes and platelets (at protein level). {ECO:0000269PubMed:18347012}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005087	Ran guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0008536	Ran GTPase binding
GO:0048487	beta-tubulin binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0032316	regulation of Ran GTPase activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005881	cytoplasmic microtubule

Protein Structure and Domains

PDB ID

MGI:1921584

InterPro

IPR001870 B30.2/SPRY domain
IPR003877 SPla/RYanodine receptor SPRY
IPR006594 LisH dimerisation motif
IPR006595 CTLH, C-terminal LisH motif
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR013144 CRA domain
IPR013720 LisH dimerisation motif, subgroup
IPR018355 SPla/RYanodine receptor subgroup
IPR024964 CTLH/CRA C-terminal to LisH motif domain

PFAM

PF00622
PF08513
PF10607

PRINTS

PIRSF

SMART

SM00449
SM00667
SM00668
SM00757

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6VN19