Version 5.4
Homo sapiens Protein: FEM1A
Summary
InnateDB Protein IDBP-19466.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FEM1A
Protein Name fem-1 homolog a (C. elegans)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000269856
InnateDB Gene IDBG-19464 (FEM1A)
Protein Structure
UniProt Annotation
Function Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit (By similarity). May participate in antiinflammatory signaling via its interaction with PTGER4. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000305}.
Disease Associations
Tissue Specificity Present in macrophages derived from peripheral blood monocytes. Also present in atheromata (at protein level). {ECO:0000269PubMed:16424369}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0031867 EP4 subtype prostaglandin E2 receptor binding
Biological Process
GO:0016567 protein ubiquitination
GO:0050728 negative regulation of inflammatory response
GO:0051438 regulation of ubiquitin-protein ligase activity
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
PFAM PF00023
PF13606
PF11929
PF12796
PRINTS PR01415
PIRSF
SMART SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BSK4
PhosphoSite PhosphoSite-Q9BSK4
TrEMBL
UniProt Splice Variant
Entrez Gene 55527
UniGene Hs.594946
RefSeq NP_061178
HUGO HGNC:16934
OMIM 613538
CCDS CCDS12135
HPRD 16888
IMGT
EMBL AJ311359 AK315554 AL359589 AL365408 AY356352 BC004988 CR749732
GenPept AAH04988 AAR10439 BAG37930 CAB94875 CAB96952 CAC85342 CAH18491

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca