Version 5.4
Mus musculus Protein: Nps
Summary
InnateDB Protein IDBP-211339.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nps
Protein Name neuropeptide S
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000095597
InnateDB Gene IDBG-211337 (Nps)
Protein Structure
UniProt Annotation
Function May play an important anorexigenic role. Modulates arousal and anxiety as well as increases locomotor activity. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations. {ECO:0000269PubMed:16279934}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0007218 neuropeptide signaling pathway
GO:0008542 visual learning
GO:0032230 positive regulation of synaptic transmission, GABAergic
GO:0045760 positive regulation of action potential
GO:0051968 positive regulation of synaptic transmission, glutamatergic
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID MGI:3642232
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P0C0P8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 100043254
UniGene Mm.192092
RefSeq NP_001157083
MGI ID
MGI Symbol Nps
OMIM
CCDS CCDS52420
HPRD
IMGT
EMBL BD168690
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca