InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACER1

Summary

InnateDB Protein

IDBP-21275.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACER1

Protein Name

alkaline ceramidase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000301452

InnateDB Gene

IDBG-21273 (ACER1)

Protein Structure

UniProt Annotation

Function

Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Mainly expressed in epidermis. {ECO:0000269PubMed:16477081}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0017040	ceramidase activity
GO:0071633	dihydroceramidase activity

Biological Process

GO:0006665	sphingolipid metabolic process
GO:0006672	ceramide metabolic process
GO:0008544	epidermis development
GO:0010446	response to alkalinity
GO:0019216	regulation of lipid metabolic process
GO:0030148	sphingolipid biosynthetic process
GO:0030154	cell differentiation
GO:0030216	keratinocyte differentiation
GO:0044281	small molecule metabolic process
GO:0046512	sphingosine biosynthetic process
GO:0046514	ceramide catabolic process
GO:0071277	cellular response to calcium ion